Xeomin 100 Units

Xeomin® – Purified Botulinum Toxin Type A for Precision Medicine and Aesthetic Applications

1. Overview & Manufacturer

Xeomin® is a botulinum toxin type A (incobotulinumtoxinA) product manufactured by Merz Pharmaceuticals GmbH, a German pharmaceutical company known for innovation in medical aesthetics and neuroscience.

Xeomin is FDA approved in the United States, EMA approved in Europe, and used globally for both aesthetic wrinkle reduction and neurotherapy.

2. What makes Xeomin unique?

Unlike other botulinum toxins, Xeomin does not contain a complex protein—only the core neurotoxin molecule. This is often referred to as the “naked toxin.”

Key benefits of this purity:

Lower risk of antibody formation with repeated use

Reduced resistance over time

Highly stable and consistent formulation

3. Ingredients & Packaging

Available in 50 U, 100 U and 200 U vials

Lyophilized (freeze-dried) powder to be reconstituted with 0.9% NaCl (sterile saline)

Manufactured according to GMP standards in Germany with pharmaceutical grade purity

4. Mechanism of action

Xeomin works by blocking the release of acetylcholine at the neuromuscular junction. This temporarily weakens or paralyzes the muscles, resulting in:

Reducing dynamic facial wrinkles

Relaxing overactive muscles

Improving control of certain neurological conditions

Reducing sweat gland activity

5. Cosmetic Indications

FDA-approved for:

Brown furrows (wrinkles between the eyebrows)

Common off-label uses:

Forehead wrinkles

Crow’s feet

Nasal lines (wrinkles on the nose)

Chin dimples

Masticatory muscle reduction (slimming the jaw)

Neck rejuvenation (fascial banding)

6. Therapeutic Indications

FDA-approved for:

Cervical dystonia (neck spasm)

Blepharospasm (eyelid spasm)

Common off-label uses:

Hyperhidrosis (excessive sweating)

Migraines chronic headache

Spasticity (upper/lower limbs)

TMJ dysfunction and bruxism

7. Onset, Duration, and Dose

Onset: 3–5 days

Peak efficacy: 7–10 days

Duration: ~3–4 months (may vary by region and dose)

Unit concentration equivalent to Botox® (1:1 conversion)

8. Storage & Handling

Unreconstituted: Store at room temperature (up to 25°C), unlike many other toxins that require refrigeration

Reconstituted: Use within manufacturer’s recommended time frame

Handle gently—do not shake

9. Safety & Contraindications

Avoid use in:

Pregnant or lactating patients

Individuals with neuromuscular disorders (e.g., myasthenia gravis)

Patients allergic to botulinum toxin

Infection active infection at the injection site

Common side effects include local pain, bruising, temporary asymmetry or mild muscle weakness. These side effects are usually self-limiting.